Phenylalanine – Uses, Side Effects, Warnings, and More



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Overview

One of the “building blocks” of protein is called phenylalanine, which is an amino acid. There are three different kinds of phenylalanine: D-phenylalanine, L-phenylalanine, and DL-phenylalanine, which is a combination of the two that are created in the lab.

The amino acid known as d-phenylalanine is not one of the necessary amino acids. Its function within the body is not fully understood at this time. One of the necessary amino acids is called L-phenylalanine. There is no other form of phenylalanine that can be found in proteins besides this one. Meat, fish, eggs, cheese, and milk are among the most important dietary sources of the amino acid L-phenylalanine.

The most prevalent usage of phenylalanine is in the treatment of a skin condition that manifests itself as the development of white patches on the skin (vitiligo). It is also used for the treatment of aged skin, pain, obesity, and a wide variety of other ailments; however, there is little credible scientific data to back up these claims.

How does it operate?

Phenylalanine is utilized by the body in the production of chemical messengers; however, it is not known exactly how phenylalanine operates.

Uses & Effectiveness

Possible Usefulness in Regards to

A condition of the skin that manifests itself as the development of white patches on the skin (vitiligo). Vitiligo can be treated successfully in both adults and children by either orally ingesting L-phenylalanine in combination with exposure to UVA or topically applying L-phenylalanine to the affected areas of the skin in conjunction with UVA exposure.

It is possible that this treatment is ineffective for attention deficit hyperactivity disorder (ADHD). Because individuals with ADHD have reduced levels of certain amino acids, including phenylalanine, it was hoped that giving patients phenylalanine might be effective in treating ADHD. However, it does not appear that ingesting phenylalanine in order to treat ADHD symptoms will provide any positive results.

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Pain that is ongoing. It does not appear that taking D-phenylalanine by mouth will lessen the pain.

There is insufficient evidence that aging affects the skin. Initial studies suggest that using a cream containing undecylenoyl phenylalanine, which is a modified version of phenylalanine, twice a day for a period of 12 weeks in order to reduce the number of age spots on the skin can be effective.

Depression. A little amount of clinical research carried out in the 1970s and 1980s suggests that L-phenylalanine or DL-phenylalanine may be helpful for treating depression. [Citation needed] [Citation needed] Having said that, this research has to be substantiated. It would appear that taking D-phenylalanine will not help depressive symptoms in a person.

Obesity. Initial findings from the study indicate that those who are fat or overweight do not benefit from L-ability phenylalanine to alleviate appetite.

Parkinson disease. The results of several preliminary studies suggest that ingesting D-phenylalanine could lessen the symptoms of Parkinson’s disease.

Acute pain.

Alcoholism.

Multiple sclerosis (MS).

Osteoarthritis.

Additional prerequisites.

In order to assess how successful phenylalanine is for various applications, additional evidence is required.

Side Effects

When taken orally, L-phenylalanine is most likely safe for consumption by the vast majority of people when consumed in amounts that are typically present in foods. When used as a medicine for a limited amount of time, L-phenylalanine consumption MAY BE SAFE. When taken as a single dose of up to 10 grams, D-phenylalanine is likely to not have any adverse effects. There is not enough trustworthy information available to determine whether or not D-phenylalanine is safe when taken at doses greater than one.

L-phenylalanine MAY BE SAFE TO APPLY TO THE SKIN IF IT IS IN THE FORM OF A CREAM AND IT IS ONLY LEFT ON FOR A SHORT TIME.

Special Precautions and Warnings

When taken orally, L-phenylalanine is most likely safe for consumption by the vast majority of people when consumed in amounts that are typically present in foods. When used as a medicine for a limited amount of time, L-phenylalanine consumption MAY BE SAFE. When taken as a single dose of up to 10 grammes, D-phenylalanine is likely to not have any adverse effects. There is not enough trustworthy information available to determine whether or not D-phenylalanine is safe when taken at doses greater than one.

L-phenylalanine MAY BE SAFE TO APPLY TO THE SKIN IF IT IS IN THE FORM OF A CREAM AND IT IS ONLY LEFT ON FOR A SHORT TIME. L-phenylalanine is LIKELY SAFE when ingested in amounts usually found in foods by pregnant patients who have normal phenylalanine levels. This holds true for both breastfeeding and consumption during pregnancy. But consuming an excessive amount of phenylalanine while pregnant can increase the risk of the baby being born with a disability. It is probably safe for individuals who metabolize phenylalanine normally and have normal levels to consume the amount of phenylalanine that is naturally present in food; nevertheless, patients should avoid taking phenylalanine supplements. Even typical amounts of phenylalanine in diet should be avoided by pregnant individuals who have high levels of the amino acid phenylalanine because they have a disorder known as phenylketonuria (PKU). For these patients, the recommendation from the experts is to follow a diet low in phenylalanine for at least 20 weeks before attempting pregnancy. It is expected that this will lower the likelihood of birth abnormalities.

Phenylalanine It is LIKELY SAFE for breastfeeding mothers whose bodies process phenylalanine normally to consume the quantity of L-phenylalanine that is found in food while they are nursing their babies. Phenylalanine However, do not take more. However, there is an insufficient quantity of trustworthy data to determine whether or not it is safe to consume L-phenylalanine at medicinally bigger levels while breastfeeding.

There is not enough trustworthy information available to determine whether or not D-phenylalanine may be used safely during pregnancy or while breastfeeding. To be on the safe side, you should avoid using it.

Phenylketonuria (PKU) and other conditions that lead to elevated amounts of phenylalanine include the following: People who have certain genetic illnesses that lead their systems to build up an excessive amount of phenylalanine should steer clear of the amino acid phenylalanine. One of these illnesses is called phenylketonuria (PKU for short). If they take in phenylalanine, those who have this condition have an increased risk of developing mental retardation, high blood pressure, stroke, and a wide variety of other serious health problems. Because PKU is such a serious condition, newborns are tested for it to detect whether or not they have the ailment and will require a particular diet to avoid the complications associated with it.

Use with extreme caution if you have schizophrenia. Phenylalanine has been shown to exacerbate the symptoms of a movement disease known as tardive dyskinesia in patients with schizophrenia.

Interactions

Significant Participation

Do not combine these medications in any way.

PHENYLALANINE is involved in the interaction with levodopa.

Parkinson’s disease is treated with the drug levodopa. Taking phenylalanine in conjunction with levodopa can exacerbate the symptoms of Parkinson’s disease. If you are currently using levodopa, you should not take phenylalanine.

Interaction that is Not Overbearing

Take precautions when using these two together.

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PHENYLALANINE and the antidepressant drugs known as MAOIs have been shown to interact.

Phenylalanine has the potential to raise levels of a molecule in the body known as tyramine. It’s possible that consuming a lot of tyramine could raise your blood pressure. However, in order to get rid of tyramine, the body will naturally break it down. In most cases, this will prevent the tyramine from leading to an increase in blood pressure. Certain antidepressants prevent the body from eliminating tyramine in its natural process of doing so. This can result in there being an excessive amount of tyramine, which can then lead to blood pressure that is dangerously high.

Phenelzine (brand name: Nardil), tranylcypromine (brand name: Parnate), and a few additional drugs are included in this category of antidepressants.

PHENYLALANINE can change the effects of certain mental health medications, specifically antipsychotic medicines.

There is a possibility that certain drugs used to treat mental problems could produce jerky muscle movements. When used with some drugs for mental problems, the use of phenylalanine may increase the likelihood of experiencing jerky muscle movements.

Some medications for mental conditions include chlorpromazine (Thorazine), clozapine (Clozaril), fluphenazine (Prolixin), haloperidol (Haldol), olanzapine (Zyprexa), perphenazine (Trilafon), prochlorperazine (Compazine), quetiapine (Seroquel), risperidone (Risperdal), thioridazine (Mellaril), thiothixene (Navane), and others.

Baclofen has a reaction with the amino acid PHENYLALANINE.

It’s possible that phenylalanine will lower the amount of baclofen that the body absorbs. When taking this combo, exercise extreme caution.

Dosing

In the course of scientific inquiry, the following doses have been investigated:

L-phenylalanine administered orally to adults at a dose of 50–100 mg/kg once a day has been found to be effective in treating vitiligo, a skin condition that results in the development of white spots on the skin. L-phenylalanine was administered at a dose of 50 mg/kg three times per week for a period of up to three months.

APPLIED TO THE SKIN In order to treat vitiligo, a skin condition that results in the development of white patches on the skin, a cream containing 10% phenylalanine has been applied to the affected areas.

CHILDREN BY MOUTH: A skin ailment known as vitiligo, which results in the development of white spots on the skin, has been treated with phenylalanine at a dose of 100 mg/kg twice weekly for three to four months.



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